15-deoxy-Δ12,14-PGJ2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats

15-deoxy-Δ12,14-PGJ2 promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis

BACKGROUND Prostaglandins (PGs), lipid autacoids derived from arachidonic acid, play a pivotal role during inflammation. PGD₂ synthase is abundantly expressed in heart tissue and PGD₂ has recently been found to induce cardiomyocyte apoptosis. PGD₂ is an unstable prostanoid metabolite; therefore the objective of the present study was to elucidate whether its final dehydration product, 15-deoxy-Δ...

Biosynthesis of 15-deoxy-∆-PGJ2 and the ligation of PPARγ

945 Introduction The PPAR nuclear hormone transcription factors heterodimerize with retinoic acid receptors to regulate expression of distinct gene cassettes (1, 2). Although three PPAR isotypes (α, δ, and γ) have been well characterized, the identity of their natural ligands remains controversial (3–6). PPARγ is expressed predominantly in adipose tissue, colon and macrophages, and to a lesser ...

Study on anti inflammatory effect of scorpion (Mesobuthus eupeus) venom in adjuvant-induced arthritis in rats

Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints as well as other organs in the body. Adjuvant-induced arthritis models in inbred rats serve as relevant models for RA, having many clinical similarities to this disease. Using honey bee venom as a treatment for Rheumatoid arthritis is an ancient therapy in various parts of the world. However scorpion ve...

Synergy between adjuvant arthritis and collagen-induced arthritis in rats

Adjuvant arthritis (AA) in rats is susceptible to cell-mediated passive transfer. Collagen-induced arthritis (CIA) in rats is susceptible to passive transfer with antibody to type II collagen. We report here the development of strikingly severe arthritis in Lewis rats as the result of synergy between passively transferred antibody to type II collagen from rats with CIA and concanavalin A (Con A...

Peroxisome Proliferator Activator Receptor-g Agonists and 15-Deoxy-D-PGJ2 Induce Apoptosis in Normal and Malignant B-Lineage Cells